Challenges in Drug Development Targeting Anti-atherosclerotic Proteins

Anti-inflammatory Disease Therapies: Challenges and Strategies in Drug Development

Abbreviations: ASC, adult stem cell line; CNS, central nervous system; COPD, chronic obstructive pulmonary disease; MS, multiple sclerosis; MSC, mesenchymal stem cell; NPCs, neural stem/precursor cells; OPCs, oligodendrocyte precursor cells; RNA, ribonucleic acid; RXR, retinoic X receptor; siRNA, small interference RNA. 122 BSTP Annual Scientific Meeting Abstracts Toxicologic Pathology, 40: 122...

Open challenges in magnetic drug targeting - onlineLibraryTPS.asp

The principle of magnetic drug targeting, wherein therapy is attached to magnetically responsive carriers and magnetic fields are used to direct that therapy to disease locations, has been around for nearly two decades. Yet our ability to safely and effectively direct therapy to where it needs to go, for instance to deep tissue targets, remains limited. To date, magnetic targeting methods have ...

Fluorescent Proteins in Drug Development

Mitochondrial Targeting for Drug Development

Challenges encountered in dermatologic drug development.

Few truly new drugs are developed primarily for the treatment of dermatologic diseases. We discuss challenges and special considerations of dermatology drug development which contribute to this relative absence of novel drugs in dermatology. The issues considered are: a) the economic potential of dermatologic drugs including the potential return on investment (ROI); b) the benefit-to-risk ratio...